Confirmation of CCR6 as a risk factor for anti-topoisomerase I antibodies in systemic sclerosis

Ochoa, Eguzkine; Martin, José Ezequiel; Assasi, Shervin; Beretta, Lorenzo; Carreira, Patricia; Guillén, Alfredo; Simeón, Carmen Pilar; Koumakis, Eugénie; Dieude, Philippe; Allanore, Yannick; García Hernández, Francisco J; Espinosa, Gerard; Castellví, Ivan; Trapiella, Jose Luis; Rodriguez, Luis; González Gay, Miguel Ángel; Egurbide, María Victoria; Sáez, Luis; Callejas Rubio, Jose Luis; Vargas Hitos, Jose Antonio; Hunzelmann, Nicolas; Riemekasten, Gabriela; Witte, Torsten; Distler, Jörg H. W; Kreuter, Alexander; Lunardi, Claudio; Santaniello, Alessandro; Tan, Filemon K; Shiels, Paul G; Herrick, Ariane; Worthington, Jane; Vonk, Madelon C; Koeleman, Bobby P; Radstake, Timothy R. D. J; Mayes, Maureen D; Martin, Javier

The current knowledge of the influence of systemic sclerosis (SSc) risk loci in the clinical sub-phenotypes is still limited. The main limitation lies in the low frequency of some sub-phenotypes which could be solved by replication studies in independent cohorts and meta-analysis between studies. In this regard, CCR6 gene variants have been recently associated with anti-topoisomerase I positive (ATA+) production in SSc patients in a candidate gene study. This gene has been proposed to have a critical role in IL-17-driven autoimmunity in human diseases.

Titolo:	Confirmation of CCR6 as a risk factor for anti-topoisomerase I antibodies in systemic sclerosis
Autori:	Ochoa, Eguzkine Martin, José Ezequiel Assasi, Shervin Beretta, Lorenzo Carreira, Patricia Guillén, Alfredo Simeón, Carmen Pilar Koumakis, Eugénie Dieude, Philippe Allanore, Yannick García Hernández, Francisco J Espinosa, Gerard Castellví, Ivan Trapiella, Jose Luis Rodriguez, Luis González Gay, Miguel Ángel Egurbide, María Victoria Sáez, Luis Callejas Rubio, Jose Luis Vargas Hitos, Jose Antonio Hunzelmann, Nicolas Riemekasten, Gabriela Witte, Torsten Distler, Jörg H. W Kreuter, Alexander LUNARDI, Claudio Santaniello, Alessandro Tan, Filemon K Shiels, Paul G Herrick, Ariane Worthington, Jane Vonk, Madelon C Koeleman, Bobby P Radstake, Timothy R. D. J Mayes, Maureen D Martin, Javier mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2015
Rivista:	CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Abstract:	The current knowledge of the influence of systemic sclerosis (SSc) risk loci in the clinical sub-phenotypes is still limited. The main limitation lies in the low frequency of some sub-phenotypes which could be solved by replication studies in independent cohorts and meta-analysis between studies. In this regard, CCR6 gene variants have been recently associated with anti-topoisomerase I positive (ATA+) production in SSc patients in a candidate gene study. This gene has been proposed to have a critical role in IL-17-driven autoimmunity in human diseases.
Handle:	http://hdl.handle.net/11562/930290
Appare nelle tipologie:	01.01 Articolo in Rivista

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