Available treatment for obesity and type 2 diabetes mellitus (T2DM) is suboptimal. Thus, identifying novel molecular target(s) exerting protective effects against these metabolic imbalances is of enormous medical significance. Sirt6 loss- and gain-of-function studies have generated confounding data regarding the role of this sirtuin on energy and glucose homeostasis, leaving unclear whether activation or inhibition of SIRT6 may be beneficial for the treatment of obesity and/or T2DM.

Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6

GALIE', Mirco;
2015-01-01

Abstract

Available treatment for obesity and type 2 diabetes mellitus (T2DM) is suboptimal. Thus, identifying novel molecular target(s) exerting protective effects against these metabolic imbalances is of enormous medical significance. Sirt6 loss- and gain-of-function studies have generated confounding data regarding the role of this sirtuin on energy and glucose homeostasis, leaving unclear whether activation or inhibition of SIRT6 may be beneficial for the treatment of obesity and/or T2DM.
2015
BAC, bacterial artificial chromosome; Diabetes; EndoRa, endogenous glucose appearance rate; GIR, glucose infusion rate; Glucose homeostasis; HCD, high-caloric diet; IPGTT, intraperitoneal glucose tolerance test; IPPTT, intraperitoneal pyruvate tolerance test; Insulin sensitivity; Rd, glucose disposal rate; Rg, tissue-specific glucose uptake rate; SIRT6 overexpression; Sirtuin; T2DM, type 2 diabetes mellitus
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/930260
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