Different strategies have been proposed to target neoangiogenesis in gliomas, besides those targeting Vascular Endothelial Growth Factor (VEGF). The chemokine Interleukin-8 (IL-8) has been shown to possess both tumorigenic and proangiogenic properties. Although different pathways of induction of IL-8 gene expression have been already elucidated, few data are available on its post-transcriptional regulation in gliomas.
Regulation of IL-8 gene expression in gliomas by microRNA miR-93
GHIMENTON, CLAUDIO;ECCHER, Albino;CANTÙ, Cinzia;BEZZERRI, Valentino;PROVEZZA, Lisa;MORETTO, Giuseppe;CHILOSI, Marco;CABRINI, GIULIO;
2015-01-01
Abstract
Different strategies have been proposed to target neoangiogenesis in gliomas, besides those targeting Vascular Endothelial Growth Factor (VEGF). The chemokine Interleukin-8 (IL-8) has been shown to possess both tumorigenic and proangiogenic properties. Although different pathways of induction of IL-8 gene expression have been already elucidated, few data are available on its post-transcriptional regulation in gliomas.
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