TNF-like ligand 1A (TL1A), a recently recognized member of the TNF superfamily, and its death domain receptor 3 (DR3), firstly identified for their relevant role in T lymphocyte homeostasis, are now well-known mediators of several immune-inflammatory diseases, ranging from rheumatoid arthritis to inflammatory bowel diseases to psoriasis, whereas no data are available on their involvement in sarcoidosis, a multisystemic granulomatous disease where a deregulated T helper (Th)1/Th17 response takes place.

TL1A/DR3 axis involvement in the inflammatory cytokine network during pulmonary sarcoidosis

CALZETTI, Federica;TAMASSIA, Nicola;CASSATELLA, Marco Antonio;
2015-01-01

Abstract

TNF-like ligand 1A (TL1A), a recently recognized member of the TNF superfamily, and its death domain receptor 3 (DR3), firstly identified for their relevant role in T lymphocyte homeostasis, are now well-known mediators of several immune-inflammatory diseases, ranging from rheumatoid arthritis to inflammatory bowel diseases to psoriasis, whereas no data are available on their involvement in sarcoidosis, a multisystemic granulomatous disease where a deregulated T helper (Th)1/Th17 response takes place.
Lung; MMP-9; Sarcoidosis; TIMP-1; TL1A/DR3; TNF family members
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/926742
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