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|Titolo:||NMDA receptors are the basis of persistent network activity in neocortex slices|
|Autori interni:||FAVERO, Morgana|
|Data di pubblicazione:||2015|
|Rivista:||JOURNAL OF NEUROPHYSIOLOGY|
|Abstract:||During behavioral quiescence the neocortex generates spontaneous slow oscillations that consist of Up and Down states. Up states are short epochs of persistent activity but their underlying source is unclear. In neocortex slices of adult mice, we monitored several cellular and network variables during the transition between a traditional buffer, that does not cause Up states, and a lower divalent cation buffer, that leads to the generation of Up states. We found that the resting Vm and input resistance of cortical cells did not change with the development of Up states. The synaptic efficacy of excitatory postsynaptic potentials mediated by non-NMDA receptors was slightly reduced but this is unlikely to facilitate the generation of Up states. On the other hand, we identified two variables that are associated with the generation of Up states; an enhancement of the intrinsic firing excitability of cortical cells and an enhancement of NMDA mediated responses evoked by electrical or optogenetic stimulation. The fact that blocking NMDA receptors abolishes Up states indicates that the enhancement in intrinsic firing excitability alone is insufficient to generate Up states. NMDA receptors have a crucial role in the generation of Up states in neocortex slices.|
|Appare nelle tipologie:||01.01 Articolo in Rivista|
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