TP53 screening could be useful in a patient stratification algorithm for adult acute lymphoblastic leukemia (ALL). TP53 mutations are more frequent in T-ALL than in B-ALL and can be detected in 14% of cases negative for recurrent fusion genes, regardless of lineage derivation. Given the negative influence on response to induction chemotherapy, we suggest that TP53 status should be investigated at diagnosis particularly in patients negative for recurrent fusion genes, where the genetic-based prognostic stratification is still limited.
TP53 mutations are frequent in adult acute lymphoblastic leukemia cases negative for recurrent fusion genes and correlate with poor response to induction therapy
BONIFACIO, Massimiliano;
2013-01-01
Abstract
TP53 screening could be useful in a patient stratification algorithm for adult acute lymphoblastic leukemia (ALL). TP53 mutations are more frequent in T-ALL than in B-ALL and can be detected in 14% of cases negative for recurrent fusion genes, regardless of lineage derivation. Given the negative influence on response to induction chemotherapy, we suggest that TP53 status should be investigated at diagnosis particularly in patients negative for recurrent fusion genes, where the genetic-based prognostic stratification is still limited.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
