In forty-four Parkinsonian patients sleep spindles were studied before and during l-DOPA or amantadine therapy. By using a "spindle counter", based on analysis of harmonic components, spindles were counted automatically. Increase of spindling was observed, less evident in patients after thalamotomy, after 1-2 months of l-DOPA treatment but only in those showing clinical improvement. After 6-24 months of l-DOPA treatment a further spindle increase was noted. Amantadine treatment gave rise to increase in spindling; however, less than that observed after 1-2 months of l-DOPA therapy. This increase in spindling observed in all clinically improved patients confirms previous observations of spindle decrease in Parkinsonism. © 1982.
Effect of L-dopa or amantadine therapy on sleep spindles in Parkinsonism
BRICOLO, Albino;
1973-01-01
Abstract
In forty-four Parkinsonian patients sleep spindles were studied before and during l-DOPA or amantadine therapy. By using a "spindle counter", based on analysis of harmonic components, spindles were counted automatically. Increase of spindling was observed, less evident in patients after thalamotomy, after 1-2 months of l-DOPA treatment but only in those showing clinical improvement. After 6-24 months of l-DOPA treatment a further spindle increase was noted. Amantadine treatment gave rise to increase in spindling; however, less than that observed after 1-2 months of l-DOPA therapy. This increase in spindling observed in all clinically improved patients confirms previous observations of spindle decrease in Parkinsonism. © 1982.
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