Psoriasis is a chronic inflammatory skin disease affecting 2–3% of worldwide population.The extent of skin involvement is variable, ranging from a few localized plaques to generalizedinvolvement. Moderate to severe psoriasis (>10% of body surface area) is frequentlyassociated with psoriatic arthritis and metabolic diseases, like abdominal obesity, diabetes,non-alcoholic fatty liver disease, dyslipidemia, metabolic syndrome, and chronic kidney disease.A common genetic background as well as several acquired risk factors links psoriasisto comorbidities. From a clinical prespective, the understanding of the patients in the contextof these comorbidities is very important to ensure that treatment is tailored to meetthe individual patient needs. Indeed, some pharmacological treatments may negativelyaffect cardio-metabolic comorbidities, and have important interactions with drugs that arecommonly used to treat them. Non-pharmacological intervention such as diet, smoking cessation,and physical exercise could both improve the response to treatments for psoriasisand reduce the cardiovascular risk.

Management of moderate to severe psoriasis in patients with metabolic comorbidities

GISONDI, Paolo;IDOLAZZI, Luca;GIROLOMONI, Giampiero
2015-01-01

Abstract

Psoriasis is a chronic inflammatory skin disease affecting 2–3% of worldwide population.The extent of skin involvement is variable, ranging from a few localized plaques to generalizedinvolvement. Moderate to severe psoriasis (>10% of body surface area) is frequentlyassociated with psoriatic arthritis and metabolic diseases, like abdominal obesity, diabetes,non-alcoholic fatty liver disease, dyslipidemia, metabolic syndrome, and chronic kidney disease.A common genetic background as well as several acquired risk factors links psoriasisto comorbidities. From a clinical prespective, the understanding of the patients in the contextof these comorbidities is very important to ensure that treatment is tailored to meetthe individual patient needs. Indeed, some pharmacological treatments may negativelyaffect cardio-metabolic comorbidities, and have important interactions with drugs that arecommonly used to treat them. Non-pharmacological intervention such as diet, smoking cessation,and physical exercise could both improve the response to treatments for psoriasisand reduce the cardiovascular risk.
psoriasis; comorbidities; conventional therapies; biological therapies
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/880191
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