Breast cancer is the most frequent female malignancyworldwide. Current strategies in breast cancer therapy,including classical chemotherapy, hormone therapy, andtargeted therapies, are usually associated with chemoresistanceand serious adverse effects. Advances in ourunderstanding of changes affecting the interactomein advanced and chemoresistant breast tumors haveprovided novel therapeutic targets, including, cyclindependent kinases, mammalian target of rapamycin,Notch, Wnt and Shh. Inhibitors of these molecules recently entered clinical trials in mono- and combinationtherapy in metastatic and chemo-resistant breastcancers. Anticancer epigenetic drugs, mainly histonedeacetylase inhibitors and DNA methyltransferase inhibitors,also entered clinical trials. Because of the complexityand heterogeneity of breast cancer, the future intherapy lies in the application of individualized tailoredregimens. Emerging therapeutic targets and the implicationsfor personalized-based therapy development inbreast cancer are herein discussed.

New targeted therapies for breast cancer: A focus on tumor microenvironmental signals and chemoresistant breast cancers

KRAMPERA, Mauro;
2014-01-01

Abstract

Breast cancer is the most frequent female malignancyworldwide. Current strategies in breast cancer therapy,including classical chemotherapy, hormone therapy, andtargeted therapies, are usually associated with chemoresistanceand serious adverse effects. Advances in ourunderstanding of changes affecting the interactomein advanced and chemoresistant breast tumors haveprovided novel therapeutic targets, including, cyclindependent kinases, mammalian target of rapamycin,Notch, Wnt and Shh. Inhibitors of these molecules recently entered clinical trials in mono- and combinationtherapy in metastatic and chemo-resistant breastcancers. Anticancer epigenetic drugs, mainly histonedeacetylase inhibitors and DNA methyltransferase inhibitors,also entered clinical trials. Because of the complexityand heterogeneity of breast cancer, the future intherapy lies in the application of individualized tailoredregimens. Emerging therapeutic targets and the implicationsfor personalized-based therapy development inbreast cancer are herein discussed.
2014
breast cancer; tumor microenvironment
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/868606
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