Despite rapid progress in describing the therapeutic potency of MSCs in experimental animal models of disease, progress in understanding their biodistribution and mechanism of action in vivo has been slow to develop. The papers contained within it addressmany of the aforementioned issues including methods totrackMSCs in vivo,mechanisms thatmediateMSCmigrationand homing including within the CNS, and novel deliverymethods to target cells to specific organs. This piece ofinformation will serve as a useful resource with respect tocurrent limitations in the field and provide insights as tohow to improve current methods to achieve more beneficialoutcomes for MSC-based therapies.
Mesenchymal Stem Cell Biodistribution, Migration, and Homing In Vivo
KRAMPERA, Mauro
2014-01-01
Abstract
Despite rapid progress in describing the therapeutic potency of MSCs in experimental animal models of disease, progress in understanding their biodistribution and mechanism of action in vivo has been slow to develop. The papers contained within it addressmany of the aforementioned issues including methods totrackMSCs in vivo,mechanisms thatmediateMSCmigrationand homing including within the CNS, and novel deliverymethods to target cells to specific organs. This piece ofinformation will serve as a useful resource with respect tocurrent limitations in the field and provide insights as tohow to improve current methods to achieve more beneficialoutcomes for MSC-based therapies.
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