We recommend for staging the use of the AJCCTNM 2009, and just for pancreas and appendix AJCC-TNM 2009 and ENETS-TNM 2006/07. The selected system should be specified in the pathologic report.We recommend NEN classification and clinical actions be based on the less favorable data in case of conflicting findings.We recommend histology as the diagnostic standard, cytology if histology is not available. We recommend classification according to WHO 2010.We recommend grading according to Ki-67 index and/or mitotic count. We recommend staging according to AJCC/UICC TNM and ENETS.We recommend routine IHC assessment of synaptophysin and CgA. We suggest IHC assessment of peptide hormones or bioamines as optional in selected cases. We recommend against routine use of other IHC markers in clinical practice.
Italian Association of Clinical Endocrinologist (AME) position statement: a stepwise clinical approach to the diagnosis of gastroenteropancreatic neuroendocrine neoplasm
CASTELLO, ROBERTO;
2014-01-01
Abstract
We recommend for staging the use of the AJCCTNM 2009, and just for pancreas and appendix AJCC-TNM 2009 and ENETS-TNM 2006/07. The selected system should be specified in the pathologic report.We recommend NEN classification and clinical actions be based on the less favorable data in case of conflicting findings.We recommend histology as the diagnostic standard, cytology if histology is not available. We recommend classification according to WHO 2010.We recommend grading according to Ki-67 index and/or mitotic count. We recommend staging according to AJCC/UICC TNM and ENETS.We recommend routine IHC assessment of synaptophysin and CgA. We suggest IHC assessment of peptide hormones or bioamines as optional in selected cases. We recommend against routine use of other IHC markers in clinical practice.
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