CATALOGO DEI PRODOTTI DELLA RICERCA
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EnglishBid is a BH3-only member of the Bcl-2 family that regulates cell death at the level of mitochondrial membranes. Full length Bid protein (flBid) becomes activated after a proteolytic cleavage catalyzed by apical caspases (tBid). The cleaved protein then promotes mitochondrial membrane permeabilization by interaction with lipids and other Bcl-2 proteins. flBid also has pro-apoptotic potential in vivo, when ectopically expressed in cells, or in vitro. Although no homologues of Bcl-2 proteins have been identified in plant genomes to date, recent evidence suggests that both Bcl-2 and Bax can fulfil similar roles when introduced into plant cells. In this study, we have constitutively expressed either flBid or tBid in plants to explore the possible cross-talk of this regulatory protein with cell death signalling pathway in Arabidopsis thaliana and Nicotiana tabacum plants.
| Titolo: | Expression of the animal pro-apoptotic protein Bid in Arabidopsis thaliana and Nicotiana tabacum |
| Autori: | |
| Data di pubblicazione: | 2014 |
| Abstract: | Bid is a BH3-only member of the Bcl-2 family that regulates cell death at the level of mitochondrial membranes. Full length Bid protein (flBid) becomes activated after a proteolytic cleavage catalyzed by apical caspases (tBid). The cleaved protein then promotes mitochondrial membrane permeabilization by interaction with lipids and other Bcl-2 proteins. flBid also has pro-apoptotic potential in vivo, when ectopically expressed in cells, or in vitro. Although no homologues of Bcl-2 proteins have been identified in plant genomes to date, recent evidence suggests that both Bcl-2 and Bax can fulfil similar roles when introduced into plant cells. In this study, we have constitutively expressed either flBid or tBid in plants to explore the possible cross-talk of this regulatory protein with cell death signalling pathway in Arabidopsis thaliana and Nicotiana tabacum plants. |
| Handle: | http://hdl.handle.net/11562/856564 |
| ISBN: | 978-88-6741-223-5 |
| Appare nelle tipologie: | 04.02 Abstract in Atti di convegno |
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