BACKGROUND: It has been shown that serum concentrations of 1,25(OH)2D3 are decreased in patients with gout. A short-term administration of allopurinol increases plasma concentrations of 1,25(OH)2D3 in mild to moderate renal failure, with or without hyperuricemia. It has been reported that subjects who perform regular vigorous and/ or moderate physical activities have higher plasma and serum 25(OH)D3 levels. However, little is known about the influence of allopurinol and/or physical exercise on serum 25(OH)D3 concentrations in humans. METHODS: We investigated the effect of allopurinol administration and/or physical activity on vitamin D metabolism by measuring serum uric acid, 25(OH)D3, and calcium levels in twelve professional soccer players. RESULTS: The athletes supplemented with allopurinol, but not those who received placebo, exhibited a significant decrease in uric acid serum concentrations after the match. We also found a significant increase in serum calcium and 25(OH)D3 concentrations in the supplemented group. CONCLUSIONS: We conclude that allopurinol administration might be an effective drug to lower hyperuricemia and treat hypovitaminosis D.
Inhibition of xanthine oxidase and exercise on serum uric acid, 25(OH)D3, and calcium concentrations.
SALVAGNO, GIAN LUCA;LIPPI, Giuseppe
2014-01-01
Abstract
BACKGROUND: It has been shown that serum concentrations of 1,25(OH)2D3 are decreased in patients with gout. A short-term administration of allopurinol increases plasma concentrations of 1,25(OH)2D3 in mild to moderate renal failure, with or without hyperuricemia. It has been reported that subjects who perform regular vigorous and/ or moderate physical activities have higher plasma and serum 25(OH)D3 levels. However, little is known about the influence of allopurinol and/or physical exercise on serum 25(OH)D3 concentrations in humans. METHODS: We investigated the effect of allopurinol administration and/or physical activity on vitamin D metabolism by measuring serum uric acid, 25(OH)D3, and calcium levels in twelve professional soccer players. RESULTS: The athletes supplemented with allopurinol, but not those who received placebo, exhibited a significant decrease in uric acid serum concentrations after the match. We also found a significant increase in serum calcium and 25(OH)D3 concentrations in the supplemented group. CONCLUSIONS: We conclude that allopurinol administration might be an effective drug to lower hyperuricemia and treat hypovitaminosis D.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
