Interferon for chronic hepatitis C in patients cured of malignancy

Cesaro, S; Rossetti, F.; MOLINER L, DE .; Crivellaro, C.; Zanesco, L.; Bortolotti, F.

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Six patients with chronic hepatitis C who were cured of malignancy were treated with recombinant interferon-alpha at the dose of 4 MU/m2 for 12 months; the post-treatment follow up period was 12 months. Therapy was stopped within 6 months in three patients because of persistently abnormal alanine aminotransferase levels. In the remaining three patients, a complete normalization of alanine aminotransferase levels was obtained during treatment but it was not maintained after the end of interferon therapy. In addition, no patient cleared hepatitis C virus ribonucleic acid in serum. These results suggest that recombinant interferon is not effective in patients with chronic hepatitis C who were cured of a previous malignancy

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/779515

Titolo:	Interferon for chronic hepatitis C in patients cured of malignancy
Autori interni:	CESARO, SIMONE
Data di pubblicazione:	1994
Rivista:	EUROPEAN JOURNAL OF PEDIATRICS
Abstract:	Six patients with chronic hepatitis C who were cured of malignancy were treated with recombinant interferon-alpha at the dose of 4 MU/m2 for 12 months; the post-treatment follow up period was 12 months. Therapy was stopped within 6 months in three patients because of persistently abnormal alanine aminotransferase levels. In the remaining three patients, a complete normalization of alanine aminotransferase levels was obtained during treatment but it was not maintained after the end of interferon therapy. In addition, no patient cleared hepatitis C virus ribonucleic acid in serum. These results suggest that recombinant interferon is not effective in patients with chronic hepatitis C who were cured of a previous malignancy
Handle:	http://hdl.handle.net/11562/779515
Appare nelle tipologie:	01.01 Articolo in Rivista

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