Glucan and LNCaP cooperate in induction of cytokine synthesis by DC. LNCaP enhance IL-1β, IL-23, IL-6 and TNF-α secretion by decreasing glucan-dependent NADPH oxidase activity, whereas glucan increases IL-12 production through NADPH oxidase-unrelated mechanisms. This cooperation is essential to elicit a substantial NK cells and CD4+ lymphocytes activity, pointing out a potential relevance of glucan in prostate cancer therapy.
Prostate carcinoma cells LNCaP differentially regulate cytokine release in dectin-1 and Toll-like receptor-stimulated human monocyte-derived dendritic cells
Marongiu, Laura;DONINI, Marta;DUSI, Stefano
2011-01-01
Abstract
Glucan and LNCaP cooperate in induction of cytokine synthesis by DC. LNCaP enhance IL-1β, IL-23, IL-6 and TNF-α secretion by decreasing glucan-dependent NADPH oxidase activity, whereas glucan increases IL-12 production through NADPH oxidase-unrelated mechanisms. This cooperation is essential to elicit a substantial NK cells and CD4+ lymphocytes activity, pointing out a potential relevance of glucan in prostate cancer therapy.
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