OBJECTIVES: To assess analytical imprecision and comparability of red blood cell distribution width (RDW) on Abbott Sapphire, Mindray BC6800, Siemens Advia 2120 and Sysmex XE-5000. DESIGN AND METHODS: Within-run imprecision was assessed on three pools and comparability using 132 inpatient samples. RESULTS: The imprecision of RDW was comprised between 0.3 and 1.2%, but the values exhibited broad variation among different analyzers, with bias exceeding the desirable quality specifications. CONCLUSIONS: Harmonization of RDW is still an unmet need.
Lack of harmonization of red blood cell distribution width (RDW). Evaluation of four hematological analyzers.
LIPPI, Giuseppe;
2014-01-01
Abstract
OBJECTIVES: To assess analytical imprecision and comparability of red blood cell distribution width (RDW) on Abbott Sapphire, Mindray BC6800, Siemens Advia 2120 and Sysmex XE-5000. DESIGN AND METHODS: Within-run imprecision was assessed on three pools and comparability using 132 inpatient samples. RESULTS: The imprecision of RDW was comprised between 0.3 and 1.2%, but the values exhibited broad variation among different analyzers, with bias exceeding the desirable quality specifications. CONCLUSIONS: Harmonization of RDW is still an unmet need.
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