Attenzione: i dati modificati non sono ancora stati salvati. Per confermare inserimenti o cancellazioni di voci è necessario confermare con il tasto SALVA/INSERISCI in fondo alla pagina
CATALOGO DEI PRODOTTI DELLA RICERCA
Relevant for various areas of human genetics,
Y-chromosomal short tandem repeats (Y-STRs) are com-
monly used for testing close paternal relationships among
individuals and populations, and for male lineage iden-
tification. However, even the widely used 17-loci Yfiler
set cannot resolve individuals and populations completely.
Here, 52 centers generated quality-controlled data of 13
rapidly mutating (RM) Y-STRs in 14,644 related and
unrelated males from 111 worldwide populations. Strik-
ingly, >99% of the 12,272 unrelated males were com-
pletely individualized. Haplotype diversity was extremely
high (global: 0.9999985, regional: 0.99836–0.9999988).
Haplotype sharing between populations was almost ab-
sent except for six (0.05%) of the 12,156 haplotypes.
Haplotype sharing within populations was generally rare
(0.8% nonunique haplotypes), significantly lower in ur-
ban (0.9%) than rural (2.1%) and highest in endogamous
groups (14.3%). Analysis of molecular variance revealed
99.98% of variation within populations, 0.018% among
populations within groups, and 0.002% among groups. Of
the 2,372 newly and 156 previously typed male relative
pairs,29% were differentiated including 27% of the 2,378
father–son pairs. Relative to Yfiler, haplotype diversity
was increased in 86% of the populations tested and over-
all male relative differentiation was raised by 23.5%. Our
study demonstrates the value of RM Y-STRs in identifying
and separating unrelated and related males and provides a
reference database.
Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats
Kaye N. Ballantyne;1;2 ‡ Arwin Ralf;1 ‡ Rachid Aboukhalid;3 Niaz M. Achakzai;4 Maria J. Anjos;5 Qasim Ayub;6 Joˇze Balaˇzic;7 Jack Ballantyne;8;9 David J. Ballard;10 Burkhard Berger;11 Cecilia Bobillo;12 Mehdi Bouabdellah;3 Helen Burri;13 Tomas Capal;Caratti, Stefano;15 Jorge C´ ardenas;16 Franc¸ois Cartault;17 Elizeu F. Carvalho;18 Monica Carvalho;5 Baowen Cheng;19 Michael D. Coble;20 David Comas;21 Daniel Corach;12 Maria E. D’Amato;22 Sean Davison;22 Peter de Knijff;23 Maria Corazon A. De Ungria;24 Ronny Decorte;25 Tadeusz Dobosz;26 Berit M. Dupuy;27 Samir Elmrghni;28 Mateusz Gliwi ´ nski;29 Sara C. Gomes;30 Laurens Grol;31 Cordula Haas;13 Erin Hanson;9 J¨urgen Henke;32 Lotte Henke;32 Fabiola Herrera Rodr´ıguez;33 Carolyn R. Hill;20 Gunilla Holmlund;34;35 Katsuya Honda;36 Uta Dorothee Immel;37 Shota Inokuchi;38 Mark A. Jobling;39 Mahmoud Kaddura;28 Jong S. Kim;40 Soon H. Kim;41 Wook Kim;42 Turi E. King;39 Eva Klausriegler;43 Daniel Kling;27 Lejla Kovaˇ cevi ´ c;44 Leda Kovatsi;45 Paweł Krajewski;46 Sergey Kravchenko;47 Maarten H. D. Larmuseau;25 Eun Young Lee;48 Ruediger Lessig;37 Ludmila A. Livshits;47 Damir Marjanovi ´ c;44 Marek Minarik;49 Natsuko Mizuno;38 Helena Moreira;50 Niels Morling;51 Meeta Mukherjee;52 Patrick Munier;17 Javaregowda Nagaraju;53 † Franz Neuhuber;43 Shengjie Nie;54 Premlaphat Nilasitsataporn;55 Takeki Nishi;36 Hye H. Oh;40 Jill Olofsson;51 Valerio Onofri;56 Jukka U. Palo;57 Horolma Pamjav;58 Walther Parson;11;59 Michal Petlach;49 Christopher Phillips;16 Rafal Ploski;60 Samayamantri P. R. Prasad;53 Dragan Primorac;59, 61;62 Gludhug A. Purnomo;63 Josephine Purps;64 Hector Rangel Villalobos;65 Krzysztof Re˛bała;29 Budsaba Rerkamnuaychoke;66 Danel Rey Gonzalez;16 Carlo Robino;15 Lutz Roewer;64 Alexandra Rosa;30;67 Antti Sajantila;57;68 Andrea Sala;12 Jazelyn M. Salvador;24 Paula Sanz;21 Cornelia Schmitt;69 Anil K. Sharma;52 Dayse A. Silva;18 Kyoung Jin Shin;48 Titia Sijen;31 Miriam Sirker;69 Daniela Siva´kova´;70 Vedrana Sˇ karo;71 Carlos Solano Matamoros;72 Luis Souto;50 Vlastimil Stenzl;14 Herawati Sudoyo;63 Denise Syndercombe Court;10 Adriano Tagliabracci;56 Duncan Taylor;73 Andreas Tillmar;34;35 Iosif S. Tsybovsky;74 Chris Tyler Smith;6 Kristiaan J. van der Gaag;23 Daniel Vanek;75;76 Ant´ onia V¨ olgyi;58 Denise Ward;77 Patricia Willemse;23 Eric P. H. Yap;78 Rita Y. Y. Yong;78 Irena Zupaniˇc Pajni ˇ. c;7;Manfred Kayser1
2014-01-01
Abstract
Relevant for various areas of human genetics,
Y-chromosomal short tandem repeats (Y-STRs) are com-
monly used for testing close paternal relationships among
individuals and populations, and for male lineage iden-
tification. However, even the widely used 17-loci Yfiler
set cannot resolve individuals and populations completely.
Here, 52 centers generated quality-controlled data of 13
rapidly mutating (RM) Y-STRs in 14,644 related and
unrelated males from 111 worldwide populations. Strik-
ingly, >99% of the 12,272 unrelated males were com-
pletely individualized. Haplotype diversity was extremely
high (global: 0.9999985, regional: 0.99836–0.9999988).
Haplotype sharing between populations was almost ab-
sent except for six (0.05%) of the 12,156 haplotypes.
Haplotype sharing within populations was generally rare
(0.8% nonunique haplotypes), significantly lower in ur-
ban (0.9%) than rural (2.1%) and highest in endogamous
groups (14.3%). Analysis of molecular variance revealed
99.98% of variation within populations, 0.018% among
populations within groups, and 0.002% among groups. Of
the 2,372 newly and 156 previously typed male relative
pairs,29% were differentiated including 27% of the 2,378
father–son pairs. Relative to Yfiler, haplotype diversity
was increased in 86% of the populations tested and over-
all male relative differentiation was raised by 23.5%. Our
study demonstrates the value of RM Y-STRs in identifying
and separating unrelated and related males and provides a
reference database.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/762563
Citazioni
ND
150
131
social impact
Conferma cancellazione
Sei sicuro che questo prodotto debba essere cancellato?
simulazione ASN
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.
La presente simulazione è stata realizzata sulla base delle specifiche raccolte sul tavolo ER del Focus Group IRIS coordinato dall’Università di Modena e Reggio Emilia e delle regole riportate nel DM 589/2018 e allegata Tabella A. Cineca, l’Università di Modena e Reggio Emilia e il Focus Group IRIS non si assumono alcuna responsabilità in merito all’uso che il diretto interessato o terzi faranno della simulazione. Si specifica inoltre che la simulazione contiene calcoli effettuati con dati e algoritmi di pubblico dominio e deve quindi essere considerata come un mero ausilio al calcolo svolgibile manualmente o con strumenti equivalenti.