Stereoselective syntheses of non-proteinogenic di- 14a,b, 15a,b and 16a,b and tripeptides 14c, 15c and 16c containing all L-valine unit and a cyclic unnatural alpha-amino acid have been accomplished starting from the L-valine derived chiral synthon 1. The conformational preferences of these unnatural peptides were investigated by H-1 NMR and IR spectroscopies and by molecular modelling calculations. X-ray analysis of pseudopeptides 15a and 15b is also reported.

Synthesis and conformational preferences of cyclic unnatural di- and tripeptides containing an L-valine unit: Part 2

PICCINELLI, FABIO;
2005

Abstract

Stereoselective syntheses of non-proteinogenic di- 14a,b, 15a,b and 16a,b and tripeptides 14c, 15c and 16c containing all L-valine unit and a cyclic unnatural alpha-amino acid have been accomplished starting from the L-valine derived chiral synthon 1. The conformational preferences of these unnatural peptides were investigated by H-1 NMR and IR spectroscopies and by molecular modelling calculations. X-ray analysis of pseudopeptides 15a and 15b is also reported.
X-RAY-ANALYSIS; 2; 6-DIAMINOPIMELIC ACID FRAMEWORK; STEREOCONTROLLED SYNTHESIS
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/736015
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