VEGF-A clinical significance in gastric cancers: Immunohistochemical analysis of a wide Italian cohort

Lastraioli, E; Boni, L; Romoli, Mr; Crescioli, S; Taddei, A; Beghelli, Stefania; Tomezzoli, Anna; Vindigni, C; Saragoni, L; Messerini, L; Bernini, M; Bencini, L; Giommoni, E; Freschi, G; Di Costanzo, F; Scarpa, Aldo; Morgagni, P; Farsi, M; Roviello, F; De Manzoni, Giovanni; Bechi, P; Arcangeli, A; Gruppo Italiano di Ricerca Cancro Gastrico,

doi:10.1016/j.ejso.2014.03.028

PURPOSE: The clinical significance of VEGF-A expression in gastric cancer (GC) has been reported with contradicting results. We analyzed the expression and clinical significance of VEGF-A in a wide Italian cohort of GC specimens. METHODS: VEGF-A expression was tested by immunohistochemistry in 507 patients with GC of all clinical stages. The impact of VEGF-A on overall survival (OS) was evaluated in conjunction with clinical and pathological parameters. RESULTS: In the Italian cohort we studied VEGF-A was not an independent prognostic factor neither at the univariate nor at multivariate analysis. CONCLUSIONS: Although frequently expressed, in our study VEGF-A was not able to discriminate between groups of patients with different risk.

Titolo:	VEGF-A clinical significance in gastric cancers: Immunohistochemical analysis of a wide Italian cohort
Autori:	Lastraioli E Boni L Romoli MR Crescioli S Taddei A BEGHELLI, Stefania Tomezzoli, Anna Vindigni C Saragoni L Messerini L Bernini M Bencini L Giommoni E Freschi G Di Costanzo F SCARPA, Aldo Morgagni P Farsi M Roviello F DE MANZONI, Giovanni Bechi P Arcangeli A Gruppo Italiano di Ricerca Cancro Gastrico mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2014
Rivista:	EUROPEAN JOURNAL OF SURGICAL ONCOLOGY
Abstract:	PURPOSE: The clinical significance of VEGF-A expression in gastric cancer (GC) has been reported with contradicting results. We analyzed the expression and clinical significance of VEGF-A in a wide Italian cohort of GC specimens. METHODS: VEGF-A expression was tested by immunohistochemistry in 507 patients with GC of all clinical stages. The impact of VEGF-A on overall survival (OS) was evaluated in conjunction with clinical and pathological parameters. RESULTS: In the Italian cohort we studied VEGF-A was not an independent prognostic factor neither at the univariate nor at multivariate analysis. CONCLUSIONS: Although frequently expressed, in our study VEGF-A was not able to discriminate between groups of patients with different risk.
Handle:	http://hdl.handle.net/11562/718965
Appare nelle tipologie:	01.01 Articolo in Rivista

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