A 58-year-old man was treated for tonsillitis with clarithromycin. On the 3rd day of treatment, he developed multiple sharply circumscribed erythematoviolaceous patches of various shapes and sizes (1–3 cm), some with a central blister, on the head , trunk and upper arms and legs. Lesions improved in 6-7 days just with discontinuation of the drug. 1 month later, hyperpigmentation with a red-bluish coloration was observed at the same sites. Patch testing with clarithromycin 10% aq. was performed on both normal skin and residual lesion. A positive erythematovesicular reaction (D2¹¹, D4¹¹) took place only on residual lesion, with a flare-up of the fixed drug eruption in previously involved skin. 20 control subjects had a negative patch test result.
Fixed drug eruption from clarithromycin
ROSINA, Paolo;
1998-01-01
Abstract
A 58-year-old man was treated for tonsillitis with clarithromycin. On the 3rd day of treatment, he developed multiple sharply circumscribed erythematoviolaceous patches of various shapes and sizes (1–3 cm), some with a central blister, on the head , trunk and upper arms and legs. Lesions improved in 6-7 days just with discontinuation of the drug. 1 month later, hyperpigmentation with a red-bluish coloration was observed at the same sites. Patch testing with clarithromycin 10% aq. was performed on both normal skin and residual lesion. A positive erythematovesicular reaction (D2¹¹, D4¹¹) took place only on residual lesion, with a flare-up of the fixed drug eruption in previously involved skin. 20 control subjects had a negative patch test result.
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