Effects of acute n-hexane and 2,5-hexanedione treatment on the striatal dopaminergic system in mice

Masotto, C.; Bisiani, C.; Camisasca, C.; Fusi, R.; Ricciardi, S.; Fonzi, N.; Perbellini, Luigi; Scatturin, M.; Mariani, C. B.; Canesi, M.

In order to investigate the effect of n-hexane and its metabolites on the Central Nervous System (CNS), we treated mice with n-hexane and 2,5-hexanedione (2,5-HD) by intraperitoneal (i.p.) administration. Gascromatographic mass spectrometric (GCMS) analyses of striatum and cerebellum revealed a consistent increase of 2,5-HD concentration at 0.5 and 2 hours after treatment and a decline to baseline levels at 24 hours. Traces of 2,5-HD were detected in the brain of control animals. Biochemical analyses revealed a precocious, short lasting, significant increase of striatal dopamine (DA) and homovanillic acid (HVA) levels. A significant increase of striatal synaptosomal DA uptake, suggesting a DA releasing effect on the dopaminergic terminals, was also observed. These results support the hypothesis of a possible role of n-hexane and its metabolites in inducing parkinsonism in humans and animals.

Titolo:	Effects of acute n-hexane and 2,5-hexanedione treatment on the striatal dopaminergic system in mice
Autori:	C. Masotto C. Bisiani C. Camisasca R. Fusi S. Ricciardi N. Fonzi PERBELLINI, Luigi M. Scatturin C. B. Mariani M. Canesi mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1995
Rivista:	JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT
Abstract:	In order to investigate the effect of n-hexane and its metabolites on the Central Nervous System (CNS), we treated mice with n-hexane and 2,5-hexanedione (2,5-HD) by intraperitoneal (i.p.) administration. Gascromatographic mass spectrometric (GCMS) analyses of striatum and cerebellum revealed a consistent increase of 2,5-HD concentration at 0.5 and 2 hours after treatment and a decline to baseline levels at 24 hours. Traces of 2,5-HD were detected in the brain of control animals. Biochemical analyses revealed a precocious, short lasting, significant increase of striatal dopamine (DA) and homovanillic acid (HVA) levels. A significant increase of striatal synaptosomal DA uptake, suggesting a DA releasing effect on the dopaminergic terminals, was also observed. These results support the hypothesis of a possible role of n-hexane and its metabolites in inducing parkinsonism in humans and animals.
Handle:	http://hdl.handle.net/11562/7072
Appare nelle tipologie:	01.01 Articolo in Rivista

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