Conventional magnetic resonance imaging (MRI) measures of multiple sclerosis (MS) patients provide limited informationabout the nature and the extent of brain damage and repair. Previous studies applied quantitative and semiquantitative MRI techniquesto assess either inflammation or demyelination or tissue degeneration in lesion tissue (1); however, MS plaques are complex andvarious since they show different degree of concomitant inflammatory and degenerative processes. For this reason, we established aclinically compatible protocol including three quantitative MRI techniques (qMRI, T1, T2, T2* relaxometry) and semiquantitativeMagnetisation Transfer Imaging (sq MRI, MTI) in order to (i) provide a comprehensive MRI fingerprint (CMF) of lesions that is moreadherent to the real underlying pathology and to (ii) assess the CMF contribution to clinical performances in patients.
Multiple Sclerosis lesion fingerprint using multicontrast MRI
Lin, YING CHIA;MENEGAZ, Gloria;
2014-01-01
Abstract
Conventional magnetic resonance imaging (MRI) measures of multiple sclerosis (MS) patients provide limited informationabout the nature and the extent of brain damage and repair. Previous studies applied quantitative and semiquantitative MRI techniquesto assess either inflammation or demyelination or tissue degeneration in lesion tissue (1); however, MS plaques are complex andvarious since they show different degree of concomitant inflammatory and degenerative processes. For this reason, we established aclinically compatible protocol including three quantitative MRI techniques (qMRI, T1, T2, T2* relaxometry) and semiquantitativeMagnetisation Transfer Imaging (sq MRI, MTI) in order to (i) provide a comprehensive MRI fingerprint (CMF) of lesions that is moreadherent to the real underlying pathology and to (ii) assess the CMF contribution to clinical performances in patients.
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