Previous works from our group showed axonal and myelin plasticity in the uninjured motor network of stroke patients with motor deficits [1-2].However, these studies focused on average MRI indexes of tract integrity namely generalized fractional anisotropy (GFA) [3] for axonal properties andmagnetization transfer ratio (MTR) [4] for myelin characteristics. These approaches offered a global view of tract remodeling but failed in revealing subtlechanges affecting only partially single motor connections. Depending on the location and extension of the stroke lesion, in fact, parts of connections mightbe more susceptible than other to plastic changes over time. In this study, we performed track-based quantitative analysis for assessing GFA and MTRvalues along the tract and characterizing their variations at large- and small-scale.
Tract-based quantitative analysis of myelin and axonal remodeling in the uninjured motor network after stroke
Lin, YING CHIA;MENEGAZ, Gloria;
2014-01-01
Abstract
Previous works from our group showed axonal and myelin plasticity in the uninjured motor network of stroke patients with motor deficits [1-2].However, these studies focused on average MRI indexes of tract integrity namely generalized fractional anisotropy (GFA) [3] for axonal properties andmagnetization transfer ratio (MTR) [4] for myelin characteristics. These approaches offered a global view of tract remodeling but failed in revealing subtlechanges affecting only partially single motor connections. Depending on the location and extension of the stroke lesion, in fact, parts of connections mightbe more susceptible than other to plastic changes over time. In this study, we performed track-based quantitative analysis for assessing GFA and MTRvalues along the tract and characterizing their variations at large- and small-scale.
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