Potassium-enriched depolarizing arrest (DA) is still the worldwide accepted method for myocardial protection. Despite animal models have demonstrated superior protection with no-potassium polarizing arrest (PA), and clinical studies reported lower perioperative myocardial enzymatic release, intra-cellular effects of PA vs DA in human myocardial specimens are still ill-defined.
Effects of polarizing microplegia vs standard high-potassium depolarizing microplegia on intracellular metabolism, pro-survival kinases, and apoptosis in humans.
Gandhi, Kushal Yogeshchandra;RUNGATSCHER, Alessio;TESSARI, Maddalena;LINARDI, Daniele;ONORATI, FRANCESCO;MAZZUCCO, Alessandro;FAGGIAN, Giuseppe
2014-01-01
Abstract
Potassium-enriched depolarizing arrest (DA) is still the worldwide accepted method for myocardial protection. Despite animal models have demonstrated superior protection with no-potassium polarizing arrest (PA), and clinical studies reported lower perioperative myocardial enzymatic release, intra-cellular effects of PA vs DA in human myocardial specimens are still ill-defined.
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