Recently, genetic risk scores (GRS), summing up the total effect of several single nucleotide polymorphisms (SNPs) in genes associated with either coronary risk or cardiovascular risk factors, have been tested for association with ischemic stroke with conflicting results. Recently an association was found between a GRS, based on 29 SNPs discovered by genome-wide association studies (GWAS) and hypertension. The score was reported to be associated with cerebrovascular events, a finding that has not been yet replicated. The aim of our study was to test the association of the same GRS with ischemic stroke in a Swedish case-control study. Twenty-nine SNPs were genotyped in 3,677 stroke cases and 2,415 controls included in the Lund Stroke Register (LSR), the Malmö Diet and Cancer (MDC) study and the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS). The analysis was conducted in the entire material, and separately for the three samples. After adjustment for hypertension, diabetes mellitus and smoking habits, the GRS was associated with ischemic stroke in the entire material [OR (95% CI) 1.086 (1.029-1.147) per SD increase in the GRS p=0.003] with similar trends in all three samples; LSR [1.050 (0.967-1.140)]; p=0.25], MDC [1.168 (1.060-1.288); p=0.002] and SHALSIS [1.124 (0.997-1.267); P=0.055].A blood pressure GRS is associated with ischemic stroke risk in three Swedish case-control studies, confirming the causal role of blood pressure in development of ischemic stroke. However, the effect size is low and most likely adds only marginally to prediction of stroke on top of traditional risk factors including hypertension.
A Genetic Risk Score for hypertension associates with the risk of ischemic stroke in a Swedish case-control study.
FAVA, Cristiano;
2013-01-01
Abstract
Recently, genetic risk scores (GRS), summing up the total effect of several single nucleotide polymorphisms (SNPs) in genes associated with either coronary risk or cardiovascular risk factors, have been tested for association with ischemic stroke with conflicting results. Recently an association was found between a GRS, based on 29 SNPs discovered by genome-wide association studies (GWAS) and hypertension. The score was reported to be associated with cerebrovascular events, a finding that has not been yet replicated. The aim of our study was to test the association of the same GRS with ischemic stroke in a Swedish case-control study. Twenty-nine SNPs were genotyped in 3,677 stroke cases and 2,415 controls included in the Lund Stroke Register (LSR), the Malmö Diet and Cancer (MDC) study and the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS). The analysis was conducted in the entire material, and separately for the three samples. After adjustment for hypertension, diabetes mellitus and smoking habits, the GRS was associated with ischemic stroke in the entire material [OR (95% CI) 1.086 (1.029-1.147) per SD increase in the GRS p=0.003] with similar trends in all three samples; LSR [1.050 (0.967-1.140)]; p=0.25], MDC [1.168 (1.060-1.288); p=0.002] and SHALSIS [1.124 (0.997-1.267); P=0.055].A blood pressure GRS is associated with ischemic stroke risk in three Swedish case-control studies, confirming the causal role of blood pressure in development of ischemic stroke. However, the effect size is low and most likely adds only marginally to prediction of stroke on top of traditional risk factors including hypertension.
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