he AA. present the longitudinal electroclinical and neuroradiological study of 55 children aged between 2 and 21 years with Tuberous Sclerosis (TS) and epilepsy in order to analyse the features having an early prognostic significance. The following parameters have been considered: Familial antecedents of epilepsy and TS. Age at onset of epilepsy and electroclinical picture. Incidence and type of extracerebral involvement. Neuroradiological picture by CT in all cases, MRI in 28. The subjects have been divided in three subsets according to intellectual level [A: I.Q. >80 (19 cases); B: I.Q. 50-80 (19 cases); C: I.Q. <50 (17 cases)]. On the other hand they have been divided in three groups following the type of the electroclinical picture; I: a peculiar type resulting from the association of partial seizures and periodic spasms; II: a picture of epileptic encephalopathy with polymorphous seizures and diffuse persistent EEG paroxysmal abnormalities; III: a picture persistently characterized by partial seizures only with more or less focal of multifocal EEG paroxysmal abnormalities. Analysing relationships between the different electroclinical pictures and the others considered parameters the AA conclude that the best and earliest prognostic parameter is constituted by the type of the electroclinical picture and not by the neuroradiological one.

Tuberous sclerosis and epilepsy: Longitudinal electroclinical and neuroradiological study of 55 subjects [EPILESSIA E SCLEROSI TUBEROSA: STUDIO ELETTROCLINICO E NEURORADIOLOGICO DI 55 SOGGETTI]

DALLA BERNARDINA, Bernardo;DARRA, Francesca;
1992

Abstract

he AA. present the longitudinal electroclinical and neuroradiological study of 55 children aged between 2 and 21 years with Tuberous Sclerosis (TS) and epilepsy in order to analyse the features having an early prognostic significance. The following parameters have been considered: Familial antecedents of epilepsy and TS. Age at onset of epilepsy and electroclinical picture. Incidence and type of extracerebral involvement. Neuroradiological picture by CT in all cases, MRI in 28. The subjects have been divided in three subsets according to intellectual level [A: I.Q. >80 (19 cases); B: I.Q. 50-80 (19 cases); C: I.Q. <50 (17 cases)]. On the other hand they have been divided in three groups following the type of the electroclinical picture; I: a peculiar type resulting from the association of partial seizures and periodic spasms; II: a picture of epileptic encephalopathy with polymorphous seizures and diffuse persistent EEG paroxysmal abnormalities; III: a picture persistently characterized by partial seizures only with more or less focal of multifocal EEG paroxysmal abnormalities. Analysing relationships between the different electroclinical pictures and the others considered parameters the AA conclude that the best and earliest prognostic parameter is constituted by the type of the electroclinical picture and not by the neuroradiological one.
Tuberous sclerosis; epiletic seizure
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/627790
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