Renal transplant recipients (RTR) present many skin diseases due both to the side effects of immunosuppressive drugs and to the drug induced chronic immunosuppression. Many of the skin diseases have only aesthetic significance, however HPV infections and skin cancers have many important consequences on the conditions of the patients. Genotype, environmental factors, generalized immunosuppression and cutaneous UV induced immunosuppression are the favouring factors of HPV infections. In the etiopathogenesis of skin cancer, in RTR, HPV infection and the mutagenic action of the immunosuppressive drug azathioprine, play an important part. We present three cases: in the first we show the correlation existing between photoexposition and HPV infection, in the second and the third the neoplastic transformation of verrucous lesions. Our work demonstrates that RTR need and accurate dermatologic follow up to prevent onset of HPV infections and skin cancers and to treat all the high risk lesions early.

Skin diseases in renal transplant recipients. A report of three cases [LE PATOLOGIE CUTANEE NEL PAZIENTE PORTATORE DI TRAPIANTO RENALE. DESCRIZIONE DI TRE CASI CLINICI]

BARBA, Annalisa;TESSARI, Gianpaolo;SCHENA, DONATELLA;CHIEREGATO, Giancarlo
1994

Abstract

Renal transplant recipients (RTR) present many skin diseases due both to the side effects of immunosuppressive drugs and to the drug induced chronic immunosuppression. Many of the skin diseases have only aesthetic significance, however HPV infections and skin cancers have many important consequences on the conditions of the patients. Genotype, environmental factors, generalized immunosuppression and cutaneous UV induced immunosuppression are the favouring factors of HPV infections. In the etiopathogenesis of skin cancer, in RTR, HPV infection and the mutagenic action of the immunosuppressive drug azathioprine, play an important part. We present three cases: in the first we show the correlation existing between photoexposition and HPV infection, in the second and the third the neoplastic transformation of verrucous lesions. Our work demonstrates that RTR need and accurate dermatologic follow up to prevent onset of HPV infections and skin cancers and to treat all the high risk lesions early.
azathioprine, cyclosporin, prednisolone; adult, article, case report, clinical article, graft rejection, human, immunosuppressive treatment, kidney transplantation, male, skin tumor, virus infection, wart virus
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/622953
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? ND
social impact