PSMA is an integral membrane glycoprotein that is overexpressed in prostate carcinomas rendering this cell surface marker an appropriate target for antibody-vehicled drugs and toxins. We have investigated PSMA biosynthesis, O and N-glycosylation, transport and association with lipid microdomains.
Prostate-specific membrane antigen associates already in the endoplasmic reticulum with lipid microdomains
CASTELLETTI, Deborah;FRACASSO, Giulio;COLOMBATTI, Marco;
2004-01-01
Abstract
PSMA is an integral membrane glycoprotein that is overexpressed in prostate carcinomas rendering this cell surface marker an appropriate target for antibody-vehicled drugs and toxins. We have investigated PSMA biosynthesis, O and N-glycosylation, transport and association with lipid microdomains.
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