D2B is a monoclonal antibody directed against an extracellular epitope of prostate-specific membrane antigen (PSMA), which is overexpressed in prostate cancer. In this study, the characteristics of D2B IgG, F(ab’)2 and Fab fragments for targeting of prostate cancer were examined in mice with prostate cancer xenografts.
Biodistribution of In-111-labeled D2B IgG, F(ab’)2 and Fab fragments in nude mice bearing human prostate cancer xenografts
FRACASSO, Giulio;COLOMBATTI, Marco;
2012-01-01
Abstract
D2B is a monoclonal antibody directed against an extracellular epitope of prostate-specific membrane antigen (PSMA), which is overexpressed in prostate cancer. In this study, the characteristics of D2B IgG, F(ab’)2 and Fab fragments for targeting of prostate cancer were examined in mice with prostate cancer xenografts.
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