Although the field of regenerative medicine is rife with unsubstantiated claims of benefit and is often biased by strong commercial interests, it is important that the legitimate scientific enterprise does not allow this noise to overshadow meaningful advances in the field. By providing a skeletal system–centric view of MSCs, the Perspective by Bianco et al. relegates the rapidly growing body of literature dedicated to exploring nonprogenitor functions of MSCs, including immunomodulation, to obscurity and undermines the efforts of legitimate and dedicated scientists to understand these functions and exploit them to achieve a therapeutic benefit in human patients. Indeed, our committee believes that the existing scientific data are sufficiently mature to warrant MSC-based clinical trials for disease indications beyond the skeletal system. However, we acknowledge that the sound establishment of MSC-based therapies requires controlled, randomized, prospective clinical trials that incorporate mechanistic-based studies to fully assess the pharmaceutical underpinnings of such therapy.
MSCs: science and trials
KRAMPERA, Mauro;
2013-01-01
Abstract
Although the field of regenerative medicine is rife with unsubstantiated claims of benefit and is often biased by strong commercial interests, it is important that the legitimate scientific enterprise does not allow this noise to overshadow meaningful advances in the field. By providing a skeletal system–centric view of MSCs, the Perspective by Bianco et al. relegates the rapidly growing body of literature dedicated to exploring nonprogenitor functions of MSCs, including immunomodulation, to obscurity and undermines the efforts of legitimate and dedicated scientists to understand these functions and exploit them to achieve a therapeutic benefit in human patients. Indeed, our committee believes that the existing scientific data are sufficiently mature to warrant MSC-based clinical trials for disease indications beyond the skeletal system. However, we acknowledge that the sound establishment of MSC-based therapies requires controlled, randomized, prospective clinical trials that incorporate mechanistic-based studies to fully assess the pharmaceutical underpinnings of such therapy.File | Dimensione | Formato | |
---|---|---|---|
Phinney et al. Nat Med 2013.pdf
solo utenti autorizzati
Tipologia:
Documento in Post-print
Licenza:
Accesso ristretto
Dimensione
115.81 kB
Formato
Adobe PDF
|
115.81 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.