in this study we have analyzed the +61 A—G polymorphism in the 50 UTR of the EGF gene in transplanted patients who have developed nonmelanocytic skin tumors to investigate the possible role of EGF polymorphism in tumorigenesis. We have found no evidence to support the hypothesis that the +61 A—G polymorphism is involved in the non-melanocytic skin tumor development in transplanted subjects undergoing immunosuppressive treatment. The non-significant younger age at tumor development of G/G carriers needs further investigation. We confirm that the only risk factors for the development of non-melanocytic skin tumor are the age at transplantation and the skin type, according to previous observations

The +61 A-G polymorphism of the epidermal growth factor gene is not associated with occurrence of non-melanocytic skin tumors in transplant recipients.

TESSARI, Gianpaolo;
2007

Abstract

in this study we have analyzed the +61 A—G polymorphism in the 50 UTR of the EGF gene in transplanted patients who have developed nonmelanocytic skin tumors to investigate the possible role of EGF polymorphism in tumorigenesis. We have found no evidence to support the hypothesis that the +61 A—G polymorphism is involved in the non-melanocytic skin tumor development in transplanted subjects undergoing immunosuppressive treatment. The non-significant younger age at tumor development of G/G carriers needs further investigation. We confirm that the only risk factors for the development of non-melanocytic skin tumor are the age at transplantation and the skin type, according to previous observations
EGF; Non melanoma skin cancer; Organ Transplantation
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/604368
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact