T cell immune function in 20 newborn infants was investigated. Previous studies showing increased spontaneous transformation and higher 3H-thymidine incorporation at lower PHA concentration in newborn infants were confirmed. A net increase in the number of active E rosette-forming lymphocytes and a slight decrease in the percentage of total E rosette-forming cells was also found. Our results suggest the presence of a subpopulation of activated T lymphocytes in the peripheral blood of newborns during the first days of life. Possible mechanisms of this activation are discussed.
T cell immune function in newborn infants
COLOMBATTI, Marco;
1980-01-01
Abstract
T cell immune function in 20 newborn infants was investigated. Previous studies showing increased spontaneous transformation and higher 3H-thymidine incorporation at lower PHA concentration in newborn infants were confirmed. A net increase in the number of active E rosette-forming lymphocytes and a slight decrease in the percentage of total E rosette-forming cells was also found. Our results suggest the presence of a subpopulation of activated T lymphocytes in the peripheral blood of newborns during the first days of life. Possible mechanisms of this activation are discussed.
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