We have studied the morphometric aspects of the thrombolytic activity of Defibrotide in experimental venous thrombosis induced by inserting a collagen-coated nylon thread into the femoral vein of rabbits. 24 hours after thrombus induction Defibrotide decreases the size of thrombi by a factor of 6; stimulation of fibrinolysis and inhibition of platelet and leucocyte recruitment are prominent. Size of the thrombus, extension of the fibrin net and platelet adhesion are also modified by Defibrotide in 7-day-old thrombi where granulation tissue has replaced the original coagulum.
Thrombolytic activity of defibrotide: a morphometric evaluation in experimental venous thrombosis
FUMAGALLI, Guido Francesco;
1989-01-01
Abstract
We have studied the morphometric aspects of the thrombolytic activity of Defibrotide in experimental venous thrombosis induced by inserting a collagen-coated nylon thread into the femoral vein of rabbits. 24 hours after thrombus induction Defibrotide decreases the size of thrombi by a factor of 6; stimulation of fibrinolysis and inhibition of platelet and leucocyte recruitment are prominent. Size of the thrombus, extension of the fibrin net and platelet adhesion are also modified by Defibrotide in 7-day-old thrombi where granulation tissue has replaced the original coagulum.
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