Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut.

Neufeld, E. J.; Skalnik, D. G.; Lievens, Patricia; Orkin, S. H.

doi:10.1038/ng0492-50

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Human CCAAT displacement protein (CDP), a putative repressor of developmentally regulated gene expression, was purified fron HeLa cells by DNA binding-site affinity chromatography. cDNA encoding CDP was obtained by immunoscreening a lambda gt11 library with antibody raised against purified protein. The deduced primary amino acid sequence of CDP reveals remarkable homology to Drosophila cut with respect to the presence of a unique homeodomain and "cut repeats". As cut participates in determination of cell fate in several tissues in Drosophila, the similarity predicts a broad role for CDP in mammalian development.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/581558

Titolo:	Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut.
Autori:	Neufeld, E. J. Skalnik, D. G. LIEVENS, Patricia Orkin, S. H. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1992
Rivista:	NATURE GENETICS
Abstract:	Human CCAAT displacement protein (CDP), a putative repressor of developmentally regulated gene expression, was purified fron HeLa cells by DNA binding-site affinity chromatography. cDNA encoding CDP was obtained by immunoscreening a lambda gt11 library with antibody raised against purified protein. The deduced primary amino acid sequence of CDP reveals remarkable homology to Drosophila cut with respect to the presence of a unique homeodomain and "cut repeats". As cut participates in determination of cell fate in several tissues in Drosophila, the similarity predicts a broad role for CDP in mammalian development.
Handle:	http://hdl.handle.net/11562/581558
Appare nelle tipologie:	01.01 Articolo in Rivista

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