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EnglishHuman CCAAT displacement protein (CDP), a putative repressor of developmentally regulated gene expression, was purified fron HeLa cells by DNA binding-site affinity chromatography. cDNA encoding CDP was obtained by immunoscreening a lambda gt11 library with antibody raised against purified protein. The deduced primary amino acid sequence of CDP reveals remarkable homology to Drosophila cut with respect to the presence of a unique homeodomain and "cut repeats". As cut participates in determination of cell fate in several tissues in Drosophila, the similarity predicts a broad role for CDP in mammalian development.
| Titolo: | Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut. | |
| Autori: | ||
| Data di pubblicazione: | 1992 | |
| Rivista: | ||
| Abstract: | Human CCAAT displacement protein (CDP), a putative repressor of developmentally regulated gene expression, was purified fron HeLa cells by DNA binding-site affinity chromatography. cDNA encoding CDP was obtained by immunoscreening a lambda gt11 library with antibody raised against purified protein. The deduced primary amino acid sequence of CDP reveals remarkable homology to Drosophila cut with respect to the presence of a unique homeodomain and "cut repeats". As cut participates in determination of cell fate in several tissues in Drosophila, the similarity predicts a broad role for CDP in mammalian development. | |
| Handle: | http://hdl.handle.net/11562/581558 | |
| Appare nelle tipologie: | 01.01 Articolo in Rivista |
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