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|Titolo:||Overexpression of N-ras oncogene and epidermal growth factor receptor gene in human glioblastomas|
|Autori interni:||GEROSA, Massimo|
|Data di pubblicazione:||1989|
|Rivista:||JOURNAL OF THE NATIONAL CANCER INSTITUTE|
|Abstract:||Five human glioblastoma cell lines were analyzed for oncogene activation with a panel of probes. Abnormal expression of the epidermal growth factor receptor (EGFr) gene was detected in four of five lines; N-ras oncogene overexpression was found in all five cell lines. These results were subsequently confirmed with fresh brain tumor and nonneoplastic brain tissue biopsy samples; increased expression of the N-ras proto-oncogene was observed in five of five glioblastomas, all of which also showed EGFr gene overexpression, but not in well-differentiated gliomas or in nonneoplastic brain tissue specimens. No significant differences in Ha-ras and Ki-ras expression were observed. Preliminary histochemical observations showed that intracellular levels of transforming growth factor alpha, a putative biochemical link between these two oncogenes, were significantly higher in glioblastoma cells than in controls.|
|Appare nelle tipologie:||01.01 Articolo in Rivista|
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