Lymphocyte subpopulations in active tuberculosis: association with disease severity and the QFT-GIT assay

Guglielmetti, L; Cazzadori, Angelo Antonio; Conti, Michela; Boccafoglio, F; Vella, Antonio; Ortolani, Riccardo; Concia, Ercole

doi:10.5588/ijtld.12.0361

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Cell-mediated immune response plays an essential role in the pathogenesis of tuberculosis (TB). We retrospectively evaluated lymphocyte subpopulations in 177 active TB patients compared to 93 healthy controls, finding a relevant decrease in total lymphocytes and CD8+ cells. Conversely, activated human leukocyte antigen (HLA-DR+) and CD4+CD57+ cells were higher in the TB group. B-1a (CD5+CD19+) lymphocytes were reduced in TB subjects, particularly those with extended and cavitary pulmonary forms, suggesting increased compartmentalisation at the infection site. QuantiFERON®-TB Gold In-Tube positive results were associated with higher HLA-DR+CD4+ and CD4+CD57+ cells, while interferon-gamma response and total lymphocyte levels were lower in advanced pulmonary TB cases.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/576751

Titolo:	Lymphocyte subpopulations in active tuberculosis: association with disease severity and the QFT-GIT assay
Autori:	Guglielmetti L CAZZADORI, Angelo Antonio CONTI, Michela Boccafoglio F VELLA, ANTONIO Ortolani, Riccardo CONCIA, Ercole mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2013
Rivista:	INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
Abstract:	Cell-mediated immune response plays an essential role in the pathogenesis of tuberculosis (TB). We retrospectively evaluated lymphocyte subpopulations in 177 active TB patients compared to 93 healthy controls, finding a relevant decrease in total lymphocytes and CD8+ cells. Conversely, activated human leukocyte antigen (HLA-DR+) and CD4+CD57+ cells were higher in the TB group. B-1a (CD5+CD19+) lymphocytes were reduced in TB subjects, particularly those with extended and cavitary pulmonary forms, suggesting increased compartmentalisation at the infection site. QuantiFERON®-TB Gold In-Tube positive results were associated with higher HLA-DR+CD4+ and CD4+CD57+ cells, while interferon-gamma response and total lymphocyte levels were lower in advanced pulmonary TB cases.
Handle:	http://hdl.handle.net/11562/576751
Appare nelle tipologie:	01.01 Articolo in Rivista

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