A carbapenem-resistant Klebsiella pneumoniae was isolated from a blood-culture of an inpatient from Libya, hospitalized in the intensive-care unit of Negrar Hospital, Italy. The clinical isolate carried the following β-lactamase genes, blaTEM -1 , blaSHV -11 , blaOXA -1 , blaCTX -M-15 and blaOXA -48 , respectively. The blaOXA -48 gene was inserted in the Tn1999.2 transposon type, carried on a conjugative, 60-kilobase plasmid, that presented an L/M backbone, hosted by a multidrug-resistant ST 101 K. pneumoniae strain. Our report highlights the international transfer of blaOXA -48 gene and the importance of screening measures of multidrug-resistant Enterobacteriaceae.
Klebsiella pneumoniae harbouring OXA-48 carbapenemase in a Libyan refugee in Italy.
KOCSIS, Erika;CORNAGLIA, Giuseppe;MAZZARIOL, Annarita
2013
Abstract
A carbapenem-resistant Klebsiella pneumoniae was isolated from a blood-culture of an inpatient from Libya, hospitalized in the intensive-care unit of Negrar Hospital, Italy. The clinical isolate carried the following β-lactamase genes, blaTEM -1 , blaSHV -11 , blaOXA -1 , blaCTX -M-15 and blaOXA -48 , respectively. The blaOXA -48 gene was inserted in the Tn1999.2 transposon type, carried on a conjugative, 60-kilobase plasmid, that presented an L/M backbone, hosted by a multidrug-resistant ST 101 K. pneumoniae strain. Our report highlights the international transfer of blaOXA -48 gene and the importance of screening measures of multidrug-resistant Enterobacteriaceae.
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