MOTIVATION: Comparative studies are encouraged by the fast increase of data availability from the latest high-throughput techniques, in particular from functional genomic studies. Yet, the size of datasets, the challenge of complete orthologs findings and not last, the variety of identification formats, make information integration challenging. With HOMECAT, we aim to facilitate cross-species relationship identification and data mapping, by combining orthology predictions from several publicly available sources, a convenient interface for high-throughput data download and automatic identifier conversion into a Cytoscape plug-in, that provides both an integration with a large set of bioinformatics tools, as well as a user-friendly interface. AVAILABILITY: HOMECAT and the Supplementary Materials are freely available at http://www.cbmc.it/homecat/. CONTACT: simone.zorzan@univr.it SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

HOMECAT: consensus homologs mapping for interspecific knowledge transfer and functional genomic data integration.

ZORZAN, Simone;LORENZETTO, Erika;ETTORRE, Michele;Pontelli, Valeria;LAUDANNA, Carlo;BUFFELLI, Mario Rosario
2013-01-01

Abstract

MOTIVATION: Comparative studies are encouraged by the fast increase of data availability from the latest high-throughput techniques, in particular from functional genomic studies. Yet, the size of datasets, the challenge of complete orthologs findings and not last, the variety of identification formats, make information integration challenging. With HOMECAT, we aim to facilitate cross-species relationship identification and data mapping, by combining orthology predictions from several publicly available sources, a convenient interface for high-throughput data download and automatic identifier conversion into a Cytoscape plug-in, that provides both an integration with a large set of bioinformatics tools, as well as a user-friendly interface. AVAILABILITY: HOMECAT and the Supplementary Materials are freely available at http://www.cbmc.it/homecat/. CONTACT: simone.zorzan@univr.it SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
HOMECAT; Cytoscape; orthology; comparative functional genomic; microarrays; Java; optic nerve crush
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/560949
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