To determine the accuracy of TRUS in evaluating the invasive cervical carcinoma response to neoadjuvant therapies. Thirty-eight patients with locally advanced squamous cell carcinoma (IB bulky-IIIB), before and after 2 cycles of systemic chemotherapy (23 pts) or concurrent chemotherapy and radiation therapy (15 pts) where examined with TRUS evaluating this parameters cervix volume, vaginal and parametrial involvement, bladder and rectal wall invasion. Imaging data were compared to findings of clinical examination (CE) and MR imaging; post-treatment and pre-treatment images were evaluated to assess the tumor response and the results were compared to histopathologic results of resected hysterectomy specimens. Pre-treatment results showed, in local staging, a substantial agreement between TRUS and MR, but not between CE and imaging procedures. Post-treatment, a statistically significant (p<0.001) decrease of the cervix volume, confirmed by histologic findings was detected diagnostic accuracy of TRUS in estimating vaginal and parametrial involvement was 81% and 86%. TRUS demonstrated an high accuracy in evaluation of tumor response, however, in same cases vaginal and parametrial involvement was overestimated.

Transrectal ultrasonography (TRUS) assessment of cervical cancer response to neoadjuvant therapies

MANFREDI, Riccardo
2000

Abstract

To determine the accuracy of TRUS in evaluating the invasive cervical carcinoma response to neoadjuvant therapies. Thirty-eight patients with locally advanced squamous cell carcinoma (IB bulky-IIIB), before and after 2 cycles of systemic chemotherapy (23 pts) or concurrent chemotherapy and radiation therapy (15 pts) where examined with TRUS evaluating this parameters cervix volume, vaginal and parametrial involvement, bladder and rectal wall invasion. Imaging data were compared to findings of clinical examination (CE) and MR imaging; post-treatment and pre-treatment images were evaluated to assess the tumor response and the results were compared to histopathologic results of resected hysterectomy specimens. Pre-treatment results showed, in local staging, a substantial agreement between TRUS and MR, but not between CE and imaging procedures. Post-treatment, a statistically significant (p<0.001) decrease of the cervix volume, confirmed by histologic findings was detected diagnostic accuracy of TRUS in estimating vaginal and parametrial involvement was 81% and 86%. TRUS demonstrated an high accuracy in evaluation of tumor response, however, in same cases vaginal and parametrial involvement was overestimated.
Chemotherapy, Gynecology, Magnetic resonance imaging, Medical imaging, Oncology, Radiotherapy, Statistical methods
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/534159
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