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EnglishWe report the fusion genes discovered by the proposed framework on experimentally validated biological samples of chronic myelogenous leukemia (CML) and on public NCBI datasets, for which Bellerophontes is able to detect the exact junction sequence. With respect to state-of-art approaches, Bellerophontes detects the same experimentally validated fusions, however, it is more selective on the total number of detected fusions and provides a more accurate set of spanning reads supporting the junctions. We finally report the fusions involving non-annotated transcripts found in CML samples.
http://hdl.handle.net/11562/513951| Titolo: | Bellerophontes: an RNA-Seq data analysis framework for chimeric transcripts discovery based on accurate fusion model |
| Autori interni: | FERRARINI, Alberto DELLEDONNE, Massimo |
| Data di pubblicazione: | 2012 |
| Rivista: | BIOINFORMATICS |
| Abstract: | We report the fusion genes discovered by the proposed framework on experimentally validated biological samples of chronic myelogenous leukemia (CML) and on public NCBI datasets, for which Bellerophontes is able to detect the exact junction sequence. With respect to state-of-art approaches, Bellerophontes detects the same experimentally validated fusions, however, it is more selective on the total number of detected fusions and provides a more accurate set of spanning reads supporting the junctions. We finally report the fusions involving non-annotated transcripts found in CML samples. |
| Handle: | http://hdl.handle.net/11562/513951 |
| Appare nelle tipologie: | 01.01 Articolo in Rivista |
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