Adhesive microbeads for the targeting delivery of anticaries agents of vegetable origin

The formulation of quinic acid, a food constituent demonstrating potential anticaries and antigingivitisproperties, was investigated in an adhesive microparticulate delivery system with the goal of improvingits effect by prolonging its residence time at the site of action. Alginate and chitosan were selected asmucoadhesive polymers. The microspheres were prepared by coacervation. Different types of alginates,polymers blends and crosslinking agent concentrations were considered and evaluated. The best resultsin terms of encapsulation efficiency, in vitro active agent release profile and in vitro adhesive properties,both to oral mucosa and to teeth surface, were obtained with a blend of Alginate Protanal LF200S:Alginate Protanal LF120LS 1:1.5 w/w, 0.1 M CaCl2, and chitosan coating, prepared by a one-step complexcoacervation method. This microparticulate delivery system showed prolonged release of quinic acid, andcould be used as an active component in chewing gums or mouthwashes for both caries and gingivitisprevention.