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EnglishOBJECTIVE: To define the role of ZAP-70+ B cells (CD19+/ZAP-70+) as a biomarker of response to B cell depletion therapy (BCDT), their relationship with clinical outcome, and their behavior during repopulation of peripheral blood in patients with rheumatoid arthritis (RA). CONCLUSION: Baseline percentage of CD19+/ZAP-70+ cells is associated with the clinical outcome after BCDT in patients with RA. Depletion of plasmablasts and pre-switch memory B cells and increase of CD19+/ZAP-70+ cells are features of the recovery of the B cell pool after BCDT.
http://hdl.handle.net/11562/501777| Titolo: | ZAP-70+ B cell subset influences response to B cell depletion therapy and early repopulation in rheumatoid arthritis. |
| Autori interni: | ALIVERNINI, Stefano |
| Data di pubblicazione: | 2012 |
| Rivista: | THE JOURNAL OF RHEUMATOLOGY |
| Abstract: | OBJECTIVE: To define the role of ZAP-70+ B cells (CD19+/ZAP-70+) as a biomarker of response to B cell depletion therapy (BCDT), their relationship with clinical outcome, and their behavior during repopulation of peripheral blood in patients with rheumatoid arthritis (RA). CONCLUSION: Baseline percentage of CD19+/ZAP-70+ cells is associated with the clinical outcome after BCDT in patients with RA. Depletion of plasmablasts and pre-switch memory B cells and increase of CD19+/ZAP-70+ cells are features of the recovery of the B cell pool after BCDT. |
| Handle: | http://hdl.handle.net/11562/501777 |
| Appare nelle tipologie: | 01.01 Articolo in Rivista |
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