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EnglishThe present invention relates to the use of an angular psoralen, trimethylangelicin (4,6,4 '-trime thy langelicin - TMA), a molecule able to correct the intracellular localisation of the membrane protein called CFTR (Cystic Fibrosis Transmembrane conductance Regulator) carrying the F508del CFTR mutation, which is altered in a sub-group of patients suffering from cystic fibrosis. Said molecule is proposed for the preparation of a medicament for the treatment of cystic fibrosis (CF) in the sub-group of patients characterised by the F508del mutation of the CFTR gene.
| Titolo: | TRIMETHYLANGELICIN AS CFTR CORRECTOR IN BRONCHIAL EPITHELIAL CELLS |
| Autori: | |
| Data di pubblicazione: | 2012 |
| Abstract: | The present invention relates to the use of an angular psoralen, trimethylangelicin (4,6,4 '-trime thy langelicin - TMA), a molecule able to correct the intracellular localisation of the membrane protein called CFTR (Cystic Fibrosis Transmembrane conductance Regulator) carrying the F508del CFTR mutation, which is altered in a sub-group of patients suffering from cystic fibrosis. Said molecule is proposed for the preparation of a medicament for the treatment of cystic fibrosis (CF) in the sub-group of patients characterised by the F508del mutation of the CFTR gene. |
| Handle: | http://hdl.handle.net/11562/501763 |
| Appare nelle tipologie: | 05.01 Brevetto |
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