Selection of types of cardiac valve substitutes for children remains controversial. Between 1976 and 1984, 166 children, 15 years of age or younger, underwent aortic (N = 53) or mitral valve replacement (N = 90) or both (N = 23). Biological prostheses were used in 84 patients and mechanical prostheses in 71; both a mitral bioprosthesis and an aortic mechanical valve were used in 11 patients. The overall early mortality was 9\%. Mean follow-up intervals were 4.1 years for the bioprosthesis group, 3.3 years for the mechanical valve group, and 3.5 years for the group receiving both. The 7 year survival rates (+/- standard error) were 63\% +/- 6\% in the bioprosthesis group and 70\% +/- 7\% in the mechanical valve group (p = NS). After aortic valve replacement the 7 year survival rates were 66\% +/- 14\% (bioprosthesis group) and 77\% +/- 9\% (mechanical valve group) (p = NS); after mitral valve replacement the rates were 65\% +/- 7\% (bioprosthesis group) and 54\% +/- 17\% (mechanical valve group) (p = NS). The incidence of thromboembolic events was 0.6\% +/- 0.4\% per patient-year in the bioprosthesis group (none after aortic valve replacement, 0.8\% +/- 0.6\% per patient-year after mitral valve replacement) and 1.4\% +/- 0.8\% per patient-year in the mechanical valve group (0.7\% +/- 0.7\% per patient-year after aortic valve replacement, 4.0\% +/- 2.8\% per patient-year after mitral valve replacement) (p = NS). The linearized rates of reoperation were 10.4\% +/- 1.8\% per patient-year (bioprosthesis group) and 2.3\% +/- 1.0\% per patient-year (mechanical valve group) (p less than 0.001). The 7 year probability rates of freedom from all valve-related complications were 43\% +/- 6\% in the bioprosthesis group and 86\% +/- 4\% in the mechanical valve group (p less than 0.001). In the aortic position, a mechanical adult-sized prosthesis can always be implanted, and satisfactory long-term results can be anticipated. In the systemic atrioventricular position, the results are less than satisfactory with either type of prosthesis; every effort should be made to preserve the natural valve of the child.

Late results after left-sided cardiac valve replacement in children.

MILANO, Aldo Domenico;
1986

Abstract

Selection of types of cardiac valve substitutes for children remains controversial. Between 1976 and 1984, 166 children, 15 years of age or younger, underwent aortic (N = 53) or mitral valve replacement (N = 90) or both (N = 23). Biological prostheses were used in 84 patients and mechanical prostheses in 71; both a mitral bioprosthesis and an aortic mechanical valve were used in 11 patients. The overall early mortality was 9\%. Mean follow-up intervals were 4.1 years for the bioprosthesis group, 3.3 years for the mechanical valve group, and 3.5 years for the group receiving both. The 7 year survival rates (+/- standard error) were 63\% +/- 6\% in the bioprosthesis group and 70\% +/- 7\% in the mechanical valve group (p = NS). After aortic valve replacement the 7 year survival rates were 66\% +/- 14\% (bioprosthesis group) and 77\% +/- 9\% (mechanical valve group) (p = NS); after mitral valve replacement the rates were 65\% +/- 7\% (bioprosthesis group) and 54\% +/- 17\% (mechanical valve group) (p = NS). The incidence of thromboembolic events was 0.6\% +/- 0.4\% per patient-year in the bioprosthesis group (none after aortic valve replacement, 0.8\% +/- 0.6\% per patient-year after mitral valve replacement) and 1.4\% +/- 0.8\% per patient-year in the mechanical valve group (0.7\% +/- 0.7\% per patient-year after aortic valve replacement, 4.0\% +/- 2.8\% per patient-year after mitral valve replacement) (p = NS). The linearized rates of reoperation were 10.4\% +/- 1.8\% per patient-year (bioprosthesis group) and 2.3\% +/- 1.0\% per patient-year (mechanical valve group) (p less than 0.001). The 7 year probability rates of freedom from all valve-related complications were 43\% +/- 6\% in the bioprosthesis group and 86\% +/- 4\% in the mechanical valve group (p less than 0.001). In the aortic position, a mechanical adult-sized prosthesis can always be implanted, and satisfactory long-term results can be anticipated. In the systemic atrioventricular position, the results are less than satisfactory with either type of prosthesis; every effort should be made to preserve the natural valve of the child.
Adolescent, Aortic Valve; surgery, Child, Child; mortality/surgery, Heart Valve Prosthesis; mortality/surgery, Thromboembolism
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/478473
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