The beneficial effect of naturally occurring flavonoids in health is believed to be due to their strong antioxidant activity. However, recent laboratory evidence indicates the involvement of a more specific action. Here, we present evidence that, among a number of catechins present in green tea extract, only epigallocatechin-3-gallate (EGCG) exerts a strong inhibitory action on interferon-gamma-elicited activation of signal transducer and activator of transcription 1 (STAT1). Protective action of EGCG in ischemia/reperfusion injury in the heart and the molecular mechanism of action, which has nothing to do with its anti-oxidant capacity are described.
Titolo: | Protective effect of epigallocatechin-3-gallate on ischemia/reperfusion-induced injuries in the heart: STAT1 silencing flavonoid. | |
Autori: | SUZUKI, Hisanori (Corresponding) | |
Data di pubblicazione: | 2007 | |
Rivista: | ||
Handle: | http://hdl.handle.net/11562/476598 | |
Appare nelle tipologie: | 01.01 Articolo in Rivista |