This study aimed to verify whether rs4986790 A >G single nucleotide polymorphism of toll like receptor 4 (TLR-4) associates with a more severe course of hepatitis B virus (HBV) chronic infection. A cross-sectional study enrolled 191 Caucasian HBV-positive patients: 28 HBsAg+ inactive carriers, 121 chronic hepatitis B, 42 HBsAg+transplant candidates. A longitudinal study included 94 patients followed-up for a median time of 19.3 years. TLR-4 rs4986790 A/A genotype was carried less frequently in male HBsAg+inactive carriers than in males with HBsAg+active chronic infection (12/17 Vs 109/121, p00.022). At stepwise logistic regression analysis, the carriage of TLR-4 rs4986790 A/A genotype was found to be and independent predictor of liver fibrosis (O.R. 14.8, p00.019). In conclusion, in HBV-positive Caucasian patients, the A/A genotype of the rs4986790 polymorphism may influence a worse outcome of chronic HBV infection, mainly through a synergistic interaction with male gender.

Toll like receptor 4 D299G associates with disease progression in caucasian patients with chronic HBV infection: relationship with gender

FATTOVICH, Giovanna;
2013

Abstract

This study aimed to verify whether rs4986790 A >G single nucleotide polymorphism of toll like receptor 4 (TLR-4) associates with a more severe course of hepatitis B virus (HBV) chronic infection. A cross-sectional study enrolled 191 Caucasian HBV-positive patients: 28 HBsAg+ inactive carriers, 121 chronic hepatitis B, 42 HBsAg+transplant candidates. A longitudinal study included 94 patients followed-up for a median time of 19.3 years. TLR-4 rs4986790 A/A genotype was carried less frequently in male HBsAg+inactive carriers than in males with HBsAg+active chronic infection (12/17 Vs 109/121, p00.022). At stepwise logistic regression analysis, the carriage of TLR-4 rs4986790 A/A genotype was found to be and independent predictor of liver fibrosis (O.R. 14.8, p00.019). In conclusion, in HBV-positive Caucasian patients, the A/A genotype of the rs4986790 polymorphism may influence a worse outcome of chronic HBV infection, mainly through a synergistic interaction with male gender.
hepatitis B virus; disease progression; toll like receptor
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/473618
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