CATALOGO DEI PRODOTTI DELLA RICERCA
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EnglishBACKGROUND: Little information is available on the influence of the storage conditions on the results of hemoglobin A2 (HbA2) and F (HbF) testing. METHODS: The stability of HbA2 and HbF was assessed on stored whole blood samples tested immediately after collection and after one week of storage at either + 4 degrees C or - 80 degrees C. RESULTS: An excellent correlation was observed between fresh specimens and those stored at either + 4 degrees C (HbA2: r = 0.994; p < 0.001 and HbF: r = 0.999; p < 0.001) or - 80 degrees C (HbA2: r = 0.995; p < 0.001 and HbF: r = 0.999; p < 0.001). The mean biases from the reference fresh specimens were very modest for samples stored at + 4 degrees C (HbA2: -0.06%; HbF: 0.02%;) and - 80 degrees C (HbA2: - 0.06%; HbF: 0.05%). CONCLUSIONS: The results of our investigation demonstrate that whole blood specimens for HbA2 and HbF testing can be stored at + 4 degrees C or - 80 degrees C for up to one week.
| Titolo: | The measurement of hemoglobin A2 and F in stored whole blood samples. |
| Autori: | |
| Data di pubblicazione: | 2011 |
| Rivista: | |
| Abstract: | BACKGROUND: Little information is available on the influence of the storage conditions on the results of hemoglobin A2 (HbA2) and F (HbF) testing. METHODS: The stability of HbA2 and HbF was assessed on stored whole blood samples tested immediately after collection and after one week of storage at either + 4 degrees C or - 80 degrees C. RESULTS: An excellent correlation was observed between fresh specimens and those stored at either + 4 degrees C (HbA2: r = 0.994; p < 0.001 and HbF: r = 0.999; p < 0.001) or - 80 degrees C (HbA2: r = 0.995; p < 0.001 and HbF: r = 0.999; p < 0.001). The mean biases from the reference fresh specimens were very modest for samples stored at + 4 degrees C (HbA2: -0.06%; HbF: 0.02%;) and - 80 degrees C (HbA2: - 0.06%; HbF: 0.05%). CONCLUSIONS: The results of our investigation demonstrate that whole blood specimens for HbA2 and HbF testing can be stored at + 4 degrees C or - 80 degrees C for up to one week. |
| Handle: | http://hdl.handle.net/11562/473427 |
| Appare nelle tipologie: | 01.01 Articolo in Rivista |
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