This is a letter in reply to Masuccio et al (J Pediatr 2009;155:454), who commented an article published by Cortese S, myself, et al. (J Pediatr 2009;154:86-90). In this letter we suggest that the cross sectional nature of our study could not allow to infer causality and psychopathological/pathophysiological pathways in the relationship between body size and depressive symptoms. Moreover, to prove that insulin resistance may lead to depressive symptoms in obese adolescents, as hypothesized by Masuccio et al., a longitudinal design and appropriate regression analyses, should be conducted.
Reply
CORTESE, Samuele;MAFFEIS, Claudio
2009-01-01
Abstract
This is a letter in reply to Masuccio et al (J Pediatr 2009;155:454), who commented an article published by Cortese S, myself, et al. (J Pediatr 2009;154:86-90). In this letter we suggest that the cross sectional nature of our study could not allow to infer causality and psychopathological/pathophysiological pathways in the relationship between body size and depressive symptoms. Moreover, to prove that insulin resistance may lead to depressive symptoms in obese adolescents, as hypothesized by Masuccio et al., a longitudinal design and appropriate regression analyses, should be conducted.
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