Treated 60 10-63 yr old anxious-neurotic inpatients complaining of insomnia with 10 or 20 mg of N-desmethyldiazepam, 200 mg of amylobarbitone sodium, or placebo, given at night. The hypnotic effects of these treatments were assessed by self-rating, psychiatrists' ratings, and night nurses' observations after 1 night's treatment and after a week of treatment, and compared with pretreatment values. The residual effects of the treatments were estimated 12 hrs after ingestion using a series of cognitive and motor tasks. No significant differences between the treatments were found after 1 night. After the week of treatment, the benzodiazepine groups were achieving the best quality of self-rated sleep with fewest subjective feelings of hang-over. Some improvement in performance was found over time for all groups. However, on 2 motor tests, the higher dose of N-desmethyldiazepam was associated with less improvement (i.e., some impairment relative to placebo was detected). (15 ref) (PsycLIT Database Copyright 1975 American Psychological Assn, all rights reserved)
The residual effects of N-desmethyldiazepam in patients
TANSELLA, Michele;ZIMMERMANN, Christa;
1974-01-01
Abstract
Treated 60 10-63 yr old anxious-neurotic inpatients complaining of insomnia with 10 or 20 mg of N-desmethyldiazepam, 200 mg of amylobarbitone sodium, or placebo, given at night. The hypnotic effects of these treatments were assessed by self-rating, psychiatrists' ratings, and night nurses' observations after 1 night's treatment and after a week of treatment, and compared with pretreatment values. The residual effects of the treatments were estimated 12 hrs after ingestion using a series of cognitive and motor tasks. No significant differences between the treatments were found after 1 night. After the week of treatment, the benzodiazepine groups were achieving the best quality of self-rated sleep with fewest subjective feelings of hang-over. Some improvement in performance was found over time for all groups. However, on 2 motor tests, the higher dose of N-desmethyldiazepam was associated with less improvement (i.e., some impairment relative to placebo was detected). (15 ref) (PsycLIT Database Copyright 1975 American Psychological Assn, all rights reserved)I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.