The prognosis of adenocarcinoma of the gastro-oesophageal junction is poor and only surgery yields long-term survival in no more than 30\% of patients. We tested a new neoadjuvant chemo-radiotherapy regimen based on the administration of weekly docetaxel and cisplatin and continuous infusion of 5-FU with concurrent radiotherapy in order to evaluate its feasibility and efficacy. Thirty-three patients enrolled in a dose-finding study and observed at the 1st Division of General Surgery of the University of Verona between January 2000 and October 2003 underwent neoadjuvant chemo-radiotherapy for gastro-oesophageal junction adenocarcinoma (Siewert type I and II). The induction treatment was completed in 97.0\% of cases with no treatment-related mortality. After completion of chemo-radiation 30 patients underwent surgery (90.9\%) while three patients did not (progression in 2 cases and chemotherapy toxicity in one). Two operated patients did not undergo resection because of liver metastasis at laparotomy (respectability: 84.8\%) and 3 more cases had incomplete tumour resection (R0-resectability: 75.8\%). No postoperative in-hospital mortality was observed. A complete response (pT0N0) was achieved in 7 cases (23.3\%) while minimal residual disease without evidence of lymph node involvement was found in a further 5 cases (16.7\%). Worthy of note is the high rate of positive histopathological responses in the later period (6 out of 8) with 4 cases presenting complete responses. This protocol regimen proved to be feasible and well tolerated. Surgery-related deaths and morbidity were not increased. A high rate of positive pathological responses was obtained particularly in the later period of the study with the increased dosage of the protocol regimen.

[Preliminary results of neoadjuvant treatment of adenocarcinoma of the gastro-esophageal junction].

PEDRAZZANI, Corrado;GIACOPUZZI, Simone;RUZZENENTE, Andrea;GUGLIELMI, Alfredo;DE MANZONI, Giovanni
2005

Abstract

The prognosis of adenocarcinoma of the gastro-oesophageal junction is poor and only surgery yields long-term survival in no more than 30\% of patients. We tested a new neoadjuvant chemo-radiotherapy regimen based on the administration of weekly docetaxel and cisplatin and continuous infusion of 5-FU with concurrent radiotherapy in order to evaluate its feasibility and efficacy. Thirty-three patients enrolled in a dose-finding study and observed at the 1st Division of General Surgery of the University of Verona between January 2000 and October 2003 underwent neoadjuvant chemo-radiotherapy for gastro-oesophageal junction adenocarcinoma (Siewert type I and II). The induction treatment was completed in 97.0\% of cases with no treatment-related mortality. After completion of chemo-radiation 30 patients underwent surgery (90.9\%) while three patients did not (progression in 2 cases and chemotherapy toxicity in one). Two operated patients did not undergo resection because of liver metastasis at laparotomy (respectability: 84.8\%) and 3 more cases had incomplete tumour resection (R0-resectability: 75.8\%). No postoperative in-hospital mortality was observed. A complete response (pT0N0) was achieved in 7 cases (23.3\%) while minimal residual disease without evidence of lymph node involvement was found in a further 5 cases (16.7\%). Worthy of note is the high rate of positive histopathological responses in the later period (6 out of 8) with 4 cases presenting complete responses. This protocol regimen proved to be feasible and well tolerated. Surgery-related deaths and morbidity were not increased. A high rate of positive pathological responses was obtained particularly in the later period of the study with the increased dosage of the protocol regimen.
Adenocarcinoma; drug therapy/pathology/surgery, Adult, Aged, Antineoplastic Agents; Phytogenic; administration /&/ dosage, Antineoplastic Combined Chemotherapy Protocols; therapeutic use, Cisplatin; administration /&/ dosage, Esophageal Neoplasms; drug therapy/pathology/surgery, Esophagogastric Junction; pathology/surgery, Female, Fluorouracil; administration /&/ dosage, Humans, Male, Middle Aged, Neoadjuvant Therapy; methods, Neoplasm Staging, Retrospective Studies, Stomach Neoplasms; drug therapy/pathology/surgery, Survival Analysis, Taxoids; administration /&/ dosage, Treatment Outcome
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/431638
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